胰岛素样生长因子2与mRNA结合蛋白2在人类癌症中的多方面的作用 (综述)
1Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.
Molecular medicine reports
|January 31, 2025
概括
胰岛素样生长因子2 mRNA结合蛋白2 (IGF2BP2) 是人类癌症的关键调节者,影响RNA的稳定性和表达. 向IGF2BP2为各种癌症类型提供了显著的治疗潜力.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 在RNA生物学,RNA生物学.
背景情况:
- 胰岛素样生长因子2 mRNA结合蛋白2 (IGF2BP2) 是一个N6 - 甲基氨酸阅读器,调节RNA稳定性和表达.
- 在许多人类癌症中观察到异常IGF2BP2表达,影响疾病的发展和进展.
- IGF2BP2影响关键的生物过程,包括增殖,转移,化学抵抗,新陈代谢,瘤免疫,干细胞和细胞死亡.
研究的目的:
- 总结IGF2BP2在人类癌症中的临床重要性.
- 讨论IGF2BP2在调节癌症生物学中的多方面的作用.
- 审查IGF2BP2抑制剂和向microRNAs用于癌症治疗.
主要方法:
- 对人类癌症IGF2BP2研究的文献综述.
- 分析IGF2BP2在各种与癌症相关的生物过程中的作用.
- 关于IGF2BP2抑制剂和向microRNAs的信息汇编.
主要成果:
- IGF2BP2在癌症扩散,转移,化学抵抗,新陈代谢,免疫,干细胞和细胞死亡中发挥着重要作用.
- 已经开发出各种化学化合物作为IGF2BP2抑制剂.
- 特定的微RNA直接向并抑制癌症中的IGF2BP2表达.
结论:
- IGF2BP2在临床上很重要,在人类癌症中具有很大的治疗点潜力.
- 通过抑制剂或微RNA向IGF2BP2为癌症治疗提供了有前途的途径.
- 对IGF2BP2的进一步研究可能会导致癌症的新疗法策略.
相关概念视频
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
TGF - β Signaling Pathway
7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K


