中年和老年男性的内皮功能障碍与低丸激素有关,与循环内皮蛋白-1的升高有关
Matthew C Babcock1, Lyndsey E DuBose1, Kerry L Hildreth1
1Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
概括
老年男性的低丸激素会加速血管衰老. 在这些男性中,较高的内分泌素-1 (ET-1) 水平与动脉流媒介扩张 (FMD) 的减少有关,这表明内分泌功能受损.
科学领域:
- 心血管生物学 心血管生物学
- 内分泌学 在内分泌学.
- 血管衰老 血管衰老
背景情况:
- 衰老男性的低丸激素与加速的血管衰老和内皮功能障碍有关.
- 将低丸激素与内皮功能障碍联系在一起的确切机制尚不清楚.
- 内膜蛋白-1 (ET-1) 是一种强大的血管收缩剂,与血管疾病有关.
研究的目的:
- 为了研究血内甲蛋白-1 (ET-1) 水平和动脉流介导扩张 (FMD) 在中年和老年男性低丸激素之间的关联.
- 为了在不同的水平组中比较内皮功能和ET-1水平.
主要方法:
- 血ET-1水平和手臂动脉口病被测量在三个组:年轻男性,中年/老年男性与正常的丸激素,和中年/老年男性与低丸激素.
- 内皮细胞ET-1表达通过参与者的子集内血管活检来评估.
- 进行统计分析以确定变量之间的关联.
主要成果:
- 与年轻男性和年龄相匹配的男性相比,低丸激素的中年/老年男性表现出明显减少的口炎.与正常丸激素的年轻男性和同龄男性相比.
- 与其他两组相比,低丸激素的男性的血ET-1水平显著更高.
- 在血ET-1水平和口病之间发现了显著的反相关性,这表明ET-1有助于内皮功能障碍.
结论:
- 低丸激素男性的加速年龄相关的内皮功能障碍与循环ET-1的升高有关.
- 高血ET-1是一种潜在的机制,有助于降低该人群的血管内皮功能.
- 低丸激素男性血ET-1增加的确切来源需要进一步调查.
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