丸激素替代疗法治疗的男性血中丸激素度的升高通过病原体减少技术减轻.
B Greenwall1, K Reeder1, W Anani1,2
1Transfusion Medicine, ARUP Laboratories, Salt Lake City, Utah, USA.
Transfusion
|January 31, 2025
概括
替代疗法 (TRT) 捐赠者具有较高的水平. 一种复合吸附装置 (CAD) 从血中有效地去除了超生理,这可能允许输血来自TRT捐赠者的产品.
科学领域:
- 血液银行和输血医疗服务
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 接受替代疗法 (TRT) 的捐献者可能需要经常捐献全血,因为红细胞瘤.
- 美国食品和药物管理局的指导方针限制了来自TRT捐献者的血产品的输血.
- 这项研究研究了TRT供体水平和缓解策略.
研究的目的:
- 来自TRT捐献者的全血成分中量化丸激素水平.
- 评估一种病原体减少技术在去除丸激素方面的有效性.
主要方法:
- 来自TRT捐献者和对照者的全血被分成红细胞和血.
- 用高性能液体染色学-并联质谱法测量丸激素水平.
- 病原体减少技术 (INTERCEPT血液系统) 应用于聚合血,在UVA光和复合吸附装置 (CAD) 步骤之前和之后取样.
主要成果:
- 与对照人群相比,TRT捐赠者在血和红细胞超体中表现出明显更高的自由和总水平.
- 在对照组和TRT捐赠者中检测到超生理水平.
- CAD化显著降低了平均自由和总的分别88%和84% (p < 0.01),而紫外线没有影响.
结论:
- TRT 捐献者在血液成分中的丸激素水平升高.
- 该CAD步骤有效地从血中去除超生理丸激素,使其在参考范围内.
- 这些发现可能支持从TRT捐赠者中输入减少病原体的血和血小板.
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