低TTG-IgA与儿科腹腔疾病中孤立球泡病理相关:在没有活检方法时代的影响
Qing Yin Wang1, Prévost Jantchou2, Martha Dirks2
1Department of Internal Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Journal of pediatric gastroenterology and nutrition
|January 31, 2025
概括
仅限于十二指甲球的儿科乳病 (CD) 显示出较低的抗体水平,并且在采用无活检方法后更频繁. 这影响了儿科CD的诊断和管理策略.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 结核病的诊断 结核病的诊断
- 免疫血清学 免疫血清学
背景情况:
- 结核病 (CD) 诊断可能是具有挑战性的,因为有点的十二指肠干涉.
- 一些儿科CD病例仅在十二指肠球体中表现出他的病理学发现.
- 这项研究研究了泡限制性CD作为一个独特的子组.
研究的目的:
- 为了确定球体限制性CD是否与较低的免疫球蛋白A抗组织转质胺酶抗体 (TTG-IgA) 标位相比,与儿童的远端十二指管CD相关.
- 评估无活检方法 (对于TTG-IgA ≥10×ULN) 对球体限制性CD诊断的相对频率的影响.
主要方法:
- 儿科CD病例的回顾性分析 (2017-2022年).
- 血清TTG-IgA水平的分类 (负面,模两可,<10×上限,≥10×上限).
- 根据马什分数和十二指肠干扰地点对活检进行分类;在2020年实施的当地无活检政策.
主要成果:
- 球体限制性CD发生在7.4%的病例中,通常与负或模两可的TTG-IgA (60.0%) 相比,远端CD (5.3%) 相比.
- 没有一个球体受限的CD病例达到TTG-IgA≥10×ULN值,与48.5%的远端CD病例不同.
- 在实施无活检方法后,球体受限CD的相对频率显著增加 (4.6%至12.4%).
结论:
- 患有孤立球泡病理的儿科腹膜炎的特征是血清TTG-IgA标位较低.
- 采用高TTG-IgA水平的无活检策略,不成比例地增加了球体受限CD的相对诊断.
- 这些发现突显了球体限制性CD的独特血清学特征,以及随着诊断指南的不断变化而改变的检测率.
更多相关视频
06:26Use of Anti-phospho-girdin Antibodies to Visualize Intestinal Tuft Cells in Free-Floating Mouse Jejunum Cryosections
Published on: March 21, 2018
11.3K
07:34Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
2.4K
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
306
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
306
01:27Histology of the Small Intestine
448
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
448
01:30Inflammatory Bowel Disease II: Crohn's Disease
172
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
172
01:30Serum Laboratory Studies, Stool Test, Breath Test
299
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
299
01:17Chronic Bowel Disorders: Introduction
385
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
385
01:23Renewal of Intestinal Stem Cells
2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K