手指下的污垢-指甲-比恶性更恶性
Sumeet Mirgh1,2, Sujata Lall2,3, Sachin Punatar1,2
1BMT Unit, Department of Medical Oncology, Tata Memorial Centre, ACTREC, Navi Mumbai, Maharashtra, India.
American journal of hematology
|January 31, 2025
概括
一名患有B细胞急性淋巴细胞白血病 (B-ALL) 的男孩在干细胞移植后患上了一种罕见的Fusarium感染,从他的指甲扩散到他的阴茎. 早期皮肤和指甲检查对于免疫力低下的患者来说至关重要,以防止这种传播.
科学领域:
- 血液学 血液学 血液学
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
背景情况:
- 一名患有复发的B细胞急性淋巴细胞白血病 (B-ALL) 的儿科患者接受了一种单独的干细胞移植.
- 这位患者患有类固醇耐药的移植对宿主疾病 (GVHD),并接受全身免疫抑制治疗.
- 相关疾病包括细胞巨乳病毒 (CMV) 反激活和结核病.
研究的目的:
- 报告一个罕见的发散的 Fusarium 感染病例在免疫功能受损的儿科患者.
- 强调在免疫功能受损的个体中警性皮肤和指甲检查的重要性.
- 突出表面感染如何导致严重的全身传播.
主要方法:
- 一个儿科病人的病例报告,该病例发生在哈普洛同一性干细胞移植后.
- 阴茎病变的临床观察和进展到干性炎.
- 来自血液和阴茎病变的微生物培养.
- 作为潜在的源头的桃菌病 (指甲真菌) 的回顾性分析.
主要成果:
- 患者患有多药耐药格兰氏阴性败血症.患者患有多药耐药格兰氏阴性败血症.
- 阴茎病变进展为干性疹,在血液和病变中发现了Fusarium.
- 此外,Fusarium从患者的指甲中培养出来,这表明血源性传播来自桃菌病.
- 确定该患者的阴茎菌病是阴茎菌感染的可能来源.
结论:
- 阴囊病可能是免疫受损患者传播的虫菌感染的重要来源.
- 及时和彻底的皮肤和指甲检查对于早期检测潜在的感染源至关重要.
- 治疗表面的真菌感染可以防止严重的,危及生命的系统传播在免疫受损的宿主.
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