解锁肠道微生物群和精神病学洞察力之间的联系在厌食症神经症:一个系统性审查
Mauro Scala1,2,3,4, Mariangela Tabone2, Marco Paolini5
1Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy.
概括
肠道微生物群的改变与神经性厌食症 (AN) 中的焦虑和抑郁症状有关. 特定的细菌种群变化与饮食障碍精神病理相关,可能会影响炎症和神经递质.
科学领域:
- 微生物组研究的研究.
- 精神病学是一个精神病学.
- 胃肠病学 胃肠病学
背景情况:
- 饮食障碍 (ED) 是复杂的心理健康状况,具有显著的胃肠道表现.
- 肠道微生物群在心理健康中的作用,包括精神病理学,是一个新兴的研究领域.
研究的目的:
- 系统地审查肠道微生物群变化与ED患者精神病理症状之间的关联.
- 探索肠道微生物群的变化及其与ED中精神药物使用的关系.
主要方法:
- 按照PRISMA指南,在生物医学数据库中进行系统的文献搜索 (开始至2024年6月).
- 由于结果异质性,存在偏见评估和叙事综合的风险.
- 包括10项研究 (7项纵向,2项横截面,1项干预) 涉及350名神经性厌食症患者 (AN) 和304名健康对照 (HC).
主要成果:
- 结果是特定于AN;没有发现微生物多样性和临床症状之间的明确联系.
- 特定的细菌种群,包括Clostridium,Roseburia,Lactobacillus,Fecalibacterium (Firmicutes) 和Bifidobacterium (Actinobacteriota),与ED精神病理相关.
- 这些相关性包括焦虑和抑郁症状.
结论:
- 微生物群的变化与AN的焦虑和抑郁症状有关.
- 这些变化可能通过短链脂肪酸 (SCFA) 调节炎症和胰岛素通路,导致神经递质失衡.
- 需要进一步的研究来证实这些发现,并调查其他EDs.
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