Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Serum levels of the C-terminal pro-peptide of type V collagen have prognostic potential and are associated with a normal subtype of desmoplasia in a retrospective cohort of patients with esophagogastric cancer.

Therapeutic advances in medical oncology·2026
Same author

Epithelial PCSK6 Promotes Proliferation and Decreases Collagen Deposition by Fibroblasts Potentially via MMP Activation.

International journal of molecular sciences·2026
Same author

Zigakibart Potently Inhibits A Proliferation-Inducing Ligand-Mediated IgA Production, Addressing IgAN Pathogenesis Root Causes.

Kidney international reports·2026
Same author

Imbalances of mitochondrial dynamics in solid tumors.

Oncogenesis·2026
Same author

Transcriptome-Based Classification of Resected Pancreatic Ductal Adenocarcinoma Enhances Prognostic Modelling Accuracy of Overall Survival Following Adjuvant Treatment.

International journal of cancer·2026
Same author

Thermally enhanced efficacy of chemotherapy potentiates cisplatin-based hyperthermic intraperitoneal chemotherapy in ovarian cancer.

Scientific reports·2026

相关实验视频

Updated: Jun 12, 2026

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

9.4K

识别C/EBPδ-修饰化合物作为潜在的抗癌剂使用高通量药物屏.

Leonie Hartl1,2, JanWillem Duitman3,4,5, Hella L Aberson1,2

  • 1Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.

Journal of cellular and molecular medicine
|January 31, 2025
PubMed
概括

研究人员发现了调节CCAAT/增强剂结合蛋白三角 (C/EBPδ) 活性的新化合物. 这些化合物,包括细胞循环抑制剂,显示了针对胰腺管道腺癌 (PDAC) 进展的潜力.

关键词:
标签: 活动 活动 活动CCAAT/增强剂结合蛋白三角形在PI3K中,PI3K是指PI3K.循环林依赖的激酶酶.药物检查屏幕的使用情况.在mTOROR中使用mTOR.胰腺管道腺癌瘤

更多相关视频

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput
00:12

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

Published on: September 22, 2019

8.5K
High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds
13:59

High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds

Published on: August 18, 2023

1.9K

相关实验视频

Last Updated: Jun 12, 2026

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

9.4K
A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput
00:12

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

Published on: September 22, 2019

8.5K
High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds
13:59

High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds

Published on: August 18, 2023

1.9K

科学领域:

  • 分子生物学分子生物学
  • 癌症研究 癌症研究
  • 药理学 药理学是指药理学的学科.

背景情况:

  • CCAAT/增强酶结合蛋白三角 (C/EBPδ) 在癌症中具有双重作用,促进某些癌症的进展,但限制胰腺管道腺癌 (PDAC) 的进展.
  • 向C/EBPδ具有临床潜力,但已知很少有化合物能够调节其活性.

研究的目的:

  • 确定调节C/EBPδ转录活性的新型小分子.
  • 了解胰腺管道腺癌 (PDAC) 中C/EBPδ的调节机制.

主要方法:

  • 使用新型eGFP报告员系统进行高通量化合物选.
  • 路径丰富分析以确定目标路径.
  • 在PDAC细胞模型中验证已识别的化合物.

主要成果:

  • 从1402种小分子抑制剂中确定了22种强大的诱导剂和18种C/EBPδ活性抑制剂.
  • 细胞循环抑制通常会增加C/EBPδ活性,而PI3K/Akt/mTOR抑制剂会降低它.
  • 四种多环素依赖激酶 (CDK) 抑制剂,强大的C/EBPδ激活剂,有限的PDAC细胞克隆扩张.

结论:

  • 这项研究为临床前研究提供了一组有价值的C/EBPδ调节化合物.
  • 这些发现提高了对C/EBPδ调节的理解,特别是在PDAC中.
  • 细胞循环调节是影响PDAC中C/EBPδ活性的一个关键机制.