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牛乳杆菌 johnsonii产生循环 (pro-trp) 和促进肠道Ca2+吸收以缓解CKD-SHPT

Xiong Zeng¹, Lihua Sun¹, Huichao Xie¹

¹Department of General Surgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 31, 2025

概括

肠道细菌,特别是Lactobacillus johnsonii,在慢性脏病患者的二次性甲状腺功能障碍中发挥着至关重要的作用. 恢复L. johnsonii水平可能为这种情况提供新的治疗策略.

科学领域:

微生物学微生物学
腎臟病學 (nephrology) 是一種醫學專業.
胃肠病学胃肠病学

背景情况:

患有慢性病 (CKD) 的患者面临二次性甲状腺功能增大症 (SHPT) 的高风险,导致器官功能障碍和死亡.
目前用于CKD-SHPT的治疗方法,包括补充剂,对所有患者都不有效,根本原因尚不清楚.

研究的目的:

为了研究肠道微生物群与慢性病中二次性甲状腺功能障碍症之间的联系.
为了确定特定的微生物物种和机制,参与不平衡和SHPT在CKD.
探索CKD-SHPT的新型治疗策略.

主要方法:

在CKD小鼠模型中,分为高和低完整副甲状腺激素 (iPTH) 组.
进行了便微生物移植和L. johnsonii殖民.
在体内和体外实验中进行了实验,以阐明循环 ((pro-trp) 和其途径的作用.

主要成果:

在高IPTH组中观察到显著的肠道微生物变化,包括乳酸菌减少和副甲状腺激增.
L. johnsonii殖民和便微生物种移植表明肠道微生物与CKD-SHPT之间存在联系.
较高的L. johnsonii水平与较温和的SHPT相关,而cyclo(pro-trp) 增强了的流入,并通过特定的细胞通路降低了iPTH水平.

结论:

牛乳杆菌 (lactobacillus johnsonii) 在CKD-SHPT的发病过程中起着至关重要的作用.
已经确定了一种涉及肠道微生物群和CKD-SHPT中不平衡的新机制.
L. johnsonii及其代谢物是CKD-SHPT治疗和药物开发的潜在治疗点.

关键词:

在Ca2+中.牛乳杆菌约翰尼尼的牛乳杆菌.慢性脏疾病慢性脏疾病循环 ((pro-trp) 是一个循环.肠道上皮细胞肠道上皮细胞二次性副甲状腺功能障碍症.

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