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核受体CAR的激活:通过增强对异生菌耐药性的能力来延缓衰老的途径

Jing Yu¹, Xiaoyan Gao¹, Hang Shi¹

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 31, 2025

概括

激活构成性安德罗斯坦受体 (CAR) 延长寿命并通过增强身体对异生菌的抵抗力来改善健康寿命,提供一种潜在的抗衰老策略.

科学领域:

老龄化和老年学
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

环境因素影响衰老和与年龄相关的疾病.
增强异生菌耐药性是一种潜在的抗衰老策略.
构成性安德罗斯坦受体 (CAR) 调节压力反应和新陈代谢.

研究的目的:

调查CAR激活对寿命和健康寿命的影响.
探索CAR对衰老的影响的潜在机制.
评估CAR激动剂作为潜在的抗衰老干预.

主要方法:

利用C. elegans,药物诱导的过早衰老小鼠和衰老加速P8 (SAMP8) 小鼠作为模型生物.
管理的CAR激动剂CITCO (人类) 和TCPOBOP (老鼠).
评估寿命,健康期,基因表达 (抗压力,解毒),环境耐药性和神经退行.

主要成果:

汽车激动剂CITCO和TCPOBOP显著延长了模型生物的寿命和健康期.
长寿效应在缺乏CAR的C. elegans (nhr-8/daf-12突变) 和CAR淘汰小鼠中减少.
在C. elegans中,CITCO激活了抗压力和排毒基因,增强了对环境逆境的抵抗力,并改善了与年龄有关的神经退行.

结论:

CAR激活可以延长寿命和健康期,可能通过增强的异生菌耐药性.
汽车激动剂代表了对衰老和与年龄有关的疾病有前途的治疗标.
这些发现表明,CAR在物种之间调节寿命方面起着保留的作用.

关键词:

与年龄相关的神经退行症.抗衰老的抗衰老的抗衰老的构成性安德罗斯坦受体 (CAR)环境刺激环境刺激异生菌耐药性异生菌耐药性

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