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在临床实践中实施DPYD系统性甲胺基因的基因定型指南

Teresa T Ho1, D Max Smith2,3, Christina L Aquilante4,5

  • 1Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Clinical pharmacology and therapeutics
|January 31, 2025
PubMed
概括

对DPYD变异的基因测试可以识别患有严重胺毒性风险的患者. 将DPYD基因型识别纳入临床实践指南,可确保更安全的甲胺剂量,并减少不良事件.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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