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在精神分裂症患者中适度至重度认知障碍的负面症状中进行间歇性甲型突发刺激:一项随机对照试验

Jing Li¹, Dan Jiang², Xingyu Huang²

¹Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.

Psychiatry and clinical neurosciences

|January 31, 2025

概括

间歇性甲爆刺激 (iTBS) 针对背中前额叶皮质,显著改善了精神分裂症患者的负面症状. 这些对负面症状和大脑激活的治疗作用在治疗后至少持续了8周.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗技术医疗技术医学技术

背景情况:

精神分裂症是一种严重的精神障碍,其特点是持续的负面症状.
精神分裂症的负面症状往往导致显著的功能障碍.
目前对负面症状的治疗方法有限,需要新的治疗方法.

研究的目的:

为了评估间歇性达爆发刺激 (iTBS) 对精神分裂症患者负面症状的疗效.
评估iTBS针对双边后中前额皮质 (DMPFC) 对认知和情绪功能的影响.
在iTBS治疗后使用功能近红外光谱 (fNIRS) 调查大脑激活模式的变化.

主要方法:

一项随机对照试验,涉及35名精神分裂症患者,这些患者有负面症状和认知障碍.
参与者被分配到针对双边DMPFC或对照组的iTBS治疗中.
标准化尺度 (PANSS,SANS,MoCA,CDSS,SDSS) 用于在多个时间点进行评估,并与fNIRS一起在口头流利性任务中进行评估.

主要成果:

与对照组 (P <0.05) 相比,iTBS组显示了负面症状 (SANS,PANSS) 的显著改善.
治疗效益,包括症状改善,在治疗后持续长达8周.
在治疗后的fNIRS显示,在iTBS组中,右下额头和右额头眼球领域的激活显著增加.

结论:

双边DMPFC iTBS是缓解精神分裂症负面症状的有希望的治疗策略.
这种神经调节技术可以增强前额叶皮层的激活,可能有助于改善症状.
iTBS为改善精神分裂症患者的功能结果提供了一个潜在的途径,这些患者有持久的负面症状.

关键词:

在 dorsomedial 前额外皮层.功能近红外光谱学近红外光谱学间歇性泰达爆发刺激负面的症状负面的症状精神分裂症是一种精神分裂症.

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