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Updated: May 30, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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设计和合成的四中[3,4-c]Pyrazole西格玛-1受体连接体的设计和合成

Giuseppe Cosentino1, Maria Dichiara1, Giuliana Costanzo1

  • 1University of Catania, Dipartimento di Scienze del Farmaco e della Salute, Viale A. Doria 6, 95125, Catania, Italy.

ChemMedChem
|January 31, 2025
PubMed
概括

研究人员开发了新型的四中[3,4-c]pyrazole化合物作为西格玛-1受体 (S1R) 配体. 化合物19显示出有希望的S1R亲和力和选择性,降低了心脏毒性风险,为更安全的S1R疗法提供了潜力.

关键词:
药品化学 药品化学 是一个分子建模分子建模西格玛-1受体是一个受体.甲基烯[3,4-c]pyrazole.pyrazole.pyrazole.pyrazole.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.pyrazol.py抑制了hERG的发生.

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