肺癌患者的身体组成变化
Deena B Snoke1, Gary S Atwood2, Emma R Bellefleur1
1Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States.
American journal of physiology. Cell physiology
|January 31, 2025
概括
癌症缓解症 (CC) 在肺癌患者中导致肌肉和脂肪消耗. 这份综述强调了纵向的身体组成变化,并指出男性更严重的肌肉损失和需要基于性别的研究.
科学领域:
- 在瘤学瘤学.
- 人体生理学 人体生理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 癌症 (CC) 是肺癌患者中普遍存在的综合征,其特征是骨肌肉和脂肪组织的消耗.
- 现有的关于肺癌中身体组成变化的研究在很大程度上是截面的,限制了对纵向动态的理解.
- 很少有研究在肺癌患者群体内纵向评估身体组成的变化.
研究的目的:
- 审查目前关于肺癌患者纵向身体组成变化的知识.
- 确定影响肌肉和脂肪组织消耗的因素,重点关注生物性别.
- 突出研究中的差距,并建议未来的方向,以了解和治疗肺癌.
主要方法:
- 对32项测量身体组成的纵向研究进行系统审查.
- 包括使用计算机断层扫描,生物电阻,双X射线吸收计或全身的研究.
- 分析了接受治疗的3,951名肺癌患者 (35%为女性) 的数据.
主要成果:
- 大多数研究报告了骨肌肉质量下降,在男性中观察到更明显的衰减.
- 在报告肌肉密度的大多数研究中,注意到肌肉骨增多 (脂肪透到肌肉中).
- 报告的肥胖变化较少,但在疾病晚期更常见的是丧.
结论:
- 纵向数据显示,肺癌患者的肌肉损耗显著,性别差异较大.
- 需要进一步的研究,以充分描述整个肺癌连续性的脂肪组织变化.
- 在研究和性别特异性分析中,均衡的性别代表对于开发有效的癌症缓解症治疗方法至关重要.
相关概念视频
01:47Lung Capacity
49.2K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
49.2K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:29Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K
01:17Other Pulmonary Disorders
799
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
799