久坐不动的行为改变了高血压人口中抑郁症和所有原因死亡风险之间的关联
Haixu Wang1, Zeming Zhou1, Lihua Zhang1
1National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing.
Journal of hypertension
|January 31, 2025
概括
久坐不动的行为显著增加了患有抑郁症的高血压患者的死亡风险. 减少坐着的时间可能有助于缓解抑郁症.
科学领域:
- 心血管健康 心血管健康
- 心理健康研究 心理健康研究
- 流行病学 流行病学
背景情况:
- 抑郁症与慢性炎症和死亡风险增加有关.
- 久坐不动行为是一种可修改的生活方式因素,可能会影响健康结果.
- 高血压是心血管疾病和死亡的主要危险因素.
研究的目的:
- 调查静坐行为是否会改变高血压患者抑郁症和死亡风险之间的关联.
- 确定长时间坐着对患有抑郁症的高血压患者存活时间的影响.
主要方法:
- 国家健康和营养检查调查数据 (2007-2018) 的分析.
- 使用健康问卷-9.9评估抑郁症.
- 通过自我报告的每日坐着时间来评估久坐行为.
- 通过国家死亡指数确定死亡人数.
- 多变量考克斯回归分析以评估相互作用效应.
主要成果:
- 这项研究包括8124名高血压患者,平均随访时间为7.3年.
- 抑郁症和每天坐 ≥6小时都与全因和心血管死亡风险的增加有关.
- 久坐时间显著改变了抑郁症和全因死亡率之间的关联 (P相互作用=0.02).
- 抑郁症在每天坐 >6小时 (HR 1.52) 的患者中增加了全因死亡风险,但在每天坐 <6小时 (HR 0.95) 的患者中没有增加.
结论:
- 久坐不动的行为起到抑郁症和高血压患者全因死亡率之间的关系的修饰作用.
- 减少久坐时间可能是改善患有抑郁症的高血压患者生存结果的关键策略.
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