延长释放药物疗法用于监禁人口中物质使用障碍:系统性审查
Amelia Woods1,2, Catherine Foley3, Katherine M Conigrave3,4,5
1National Drug and Alcohol Research Centre (NDARC), University of New South Wales, Randwick, Australia.
Addiction (Abingdon, England)
|January 31, 2025
概括
延长释放布伦诺芬在减少阿片类药物使用和改善刑事司法系统中治疗保留方面表现有前途. 对于这个人群,延长释放纳尔德的有效性仍然不清楚.
科学领域:
- 成 药物 药物 药物 药物
- 刑事司法 卫生 刑事司法 卫生
- 药物治疗 药物治疗
背景情况:
- 毒品使用 (SU) 在刑事司法系统 (CJS) 中很常见,但治疗的机会有限.
- 评估监禁人员有效的药物疗法至关重要.
研究的目的:
- 评估延长释放纳尔德 (XR-NTX) 和延长释放布伦诺芬 (XR-BUP) 对CJS患者的疗效.
- 在监狱环境中综合这些药物治疗物质使用障碍的证据.
主要方法:
- 在多个数据库 (Scopus,PubMed,Embase等) 中进行系统的文献搜索. 从2002年至2022年期间.
- 包括对患有SU疾病的成年人 (18+) 的研究,XR治疗和最近的监禁.
- 使用RoB-2,ROBINS-I,JBI,以及Evers等人进行偏差风险评估. 工具. 工具. 这些工具.
主要成果:
- 分析了16项研究 (25篇论文),涉及3403名参与者.
- 在大多数阿片类药物使用研究中,XR-NTX显示了保留和SU的混合结果,在大多数阿片类药物使用研究中没有明显的优势.
- XR-BUP与语言下布伦诺芬相比,改善或相当于保留,具有混合的SU结果;没有观察到过量剂量的差异.
结论:
- 目前的证据并不清楚地支持XR-NTX或XR-BUP在CJS患者群体中的短效配方.
- 越来越多的证据表明,XR-BUP可以有效地减少阿片类药物使用,并提高该群体的治疗保留率.
- 尽管初始的药物开支,XR-BUP可能会提供成本优势.
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