动脉硬和心房肌病的标志物
Magdalena Okrajni1, Pyotr Platonov2, Iram Faqir Muhammad1
1Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
概括
通过c-f PWV和Aix75测量的动脉硬与较少的过早心房综合体 (PAC) 有关. 然而,动脉硬度和P波指数之间没有发现任何关联,这表明与心房肌病有复杂的关系.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 电子生理学 电子生理学
背景情况:
- 动脉硬,通过带-大腿脉冲波速率 (c-f PWV) 和心率校正增强指数 (Aix75) 评估,是已知的心血管疾病风险因素.
- 以前的研究表明,动脉硬与发生性心房动 (AF) 之间存在联系.
研究的目的:
- 为了研究动脉硬与心房肌病症标志物之间的关联.
- 为了确定动脉硬是否与AF风险的结构和电动心房变化相关.
主要方法:
- 从瑞典心肺生物图像研究中对1050名参与者的横截面研究.
- 在所有参与者中测量了关节-关节脉冲波速率 (c-f PWV) 和Aix75.
- 对子样本 (n=331) 进行心声扫描,以评估P波持续时间,左心房体积指数 (LAVi),V1中的P波终端力 (PWTFV1) 和P波轴.
- 多变量回归模型用于分析动脉硬和心房肌病标志物之间的关联,包括过早心房综合体 (PAC).
主要成果:
- 增加的动脉硬度 (每 1 m/s c-f PWV 增加) 与明显较少的PACs (IRR 0.45) 相关.
- 艾克斯75的增加也与PAC的减少有关 (IRR为0.66).
- 动脉硬与P波持续时间或异常PWTFV1.1之间没有发现显著的关联.
结论:
- 通过c-f PWV或Aix75测量的动脉硬度与减少的PACs有关.
- 动脉硬度和P波指数之间没有观察到任何关联,这表明存在复杂的关系.
- 需要进一步的研究,以充分理解动脉硬和心房肌病之间的联系.
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