帕金森病中的光盘色:英国生物库研究
Samuel Gibbon1,2, David P Breen1,3,4, Thomas J MacGillivray1,2
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
概括
光盘白与帕金森病 (PD) 有关. 增加的色与疾病持续时间相关,这表明其在 fundus 图像中作为神经退行性生物标志物的潜力.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 通过光学连贯断层扫描检测到的视网膜变化显示为帕金森病 (PD) 的早期生物标志物具有前途.
- 眼科生物标志物为PD诊断和监测提供了潜力.
研究的目的:
- 为了研究光盘在底镜图像中的光盘白与流行和发病的帕金森病 (PD) 之间的联系.
主要方法:
- 来自787名英国生物库参与者的彩色基底照片的分析,包括患有流行PD,事件PD和对照的人.
- 在多个区域中半自动量化光盘白.
- 对共变量调整后的逻辑和线性回归模型,以评估与PD状态和持续时间的关联.
主要成果:
- 与对照组相比,患有PD的参与者在全球和几个区域的光学盘显著变淡.
- 自PD诊断以来的每一年都与全球光盘白的增加相关,尽管这对异常值敏感.
- 在事件PD组中没有发现任何显著的关联.
结论:
- 光盘白与帕金森病 (PD) 有着显著的关联.
- 光盘的白可能会随着PD持续时间的增加而增加,这表明它有可能成为神经退行症的生物标志物.
- 在 fundus 照片中测量出的 Pallor 可以作为 PD 相关神经退行症的生物标志物.
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