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通过迈克尔添加用于控制药物释放和增强机械性能的pH响应SA/PEGDA/AS-POSS水凝的开发

Yang Meng¹, Wen Li¹, Lingji Zhang¹

¹College of Materials and Chemical Engineering, Zhengzhou University of Light Industry, Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou, PR China.

Chemistry (Weinheim an der Bergstrasse, Germany)

|January 31, 2025

概括

这项研究开发了使用酸盐和AS-POSS.的pH响应纳米复合物水凝. 这些水凝显示出增强的药物递送能力和生物相容性,使它们成为生物医学应用的有希望的.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
聚合物化学聚合物化学

背景情况:

开发先进的药物输送系统对于向治疗至关重要.
响应pH的水凝提供受控释放机制.
多面体寡合性丝素 (POSS) 可以增强水凝的特性.

研究的目的:

为了合成和描述新型的响应pH的SA/PEGDA/AS-POSS纳米复合物水凝.
为了评估水凝的pH敏感度,机械性能和药物加载/释放特征.
评估用于药物输送的水凝的生物相容性和治疗潜力.

主要方法:

硫化藻酸盐 (SA) 和AS-POSS.的合成
通过迈克尔加法反应制备SA/PEGDA/AS-POSS水凝.
水凝结构的表征,胀行为,机械强度,以及多克索鲁比 (DOX) 的加载/释放动力学.
在体外细胞毒性和杀伤瘤功效的评估.

主要成果:

成功合成了响应pH的SA/PEGDA/AS-POSS纳米复合物水凝.
增加的AS-POSS含量导致了更密集的网络,更好的机械性能和pH依赖的胀.
提高了多克索鲁比辛负载 (85.7%) 和封装效率 (72.1%).
在酸性环境中实现药物快速释放 (80.4%的累积释放),具有出色的向和受控释放.
证明了良好的生物相容性和有效的瘤杀伤能力.

结论:

开发的SA/PEGDA/AS-POSS水凝具有出色的pH反应能力和机械稳定性.
这些水凝显示出作为向癌症治疗的有效药物载体的巨大潜力.
该研究强调了AS-POSS纳入先进生物医学材料开发的希望.

关键词:

复合凝凝是一种复合凝.毒品运输商毒品运输商迈克尔的加法反应反应.多面体的寡合性丝二氧化.甲基酸盐的使用方法

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