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在ICSI中评估辅助卵细胞激活的有效性:双重分析和系统证据评估

Mohamed Fawzy¹, Mohamad AlaaEldein Elsuity^1,2, Yasmin Magdi³

¹IbnSina (Sohag), Banon (Assiut), Amshag (Sohag) IVF Facilities, Egypt.

BJOG : an international journal of obstetrics and gynaecology

|January 31, 2025

概括

人工卵细胞激活 (AOA) 在特定情况下可以改善受精,但在细胞内质精子注射 (ICSI) 周期中不会提高胚胎发育或活产率. 严格的证据是临床决策的关键.

科学领域:

生殖医学生殖医学
辅助生殖技术辅助生殖技术
在体外受精过程中受精.

背景情况:

人工卵细胞激活 (AOA) 是一种辅助生殖技术.
它用于增加细胞内质精子注射 (ICSI) 周期中的受精率.
对AOA的临床有效性需要彻底评估.

研究的目的:

评估AOA在改善受精,胚胎发育和活产率方面的有效性.
综合来自各种研究设计的证据,在ICSI中评估AOA.
确定AOA在不同患者群体中的影响.

主要方法:

在PubMed,Cochrane和Scopus (1990-2024) 中进行了系统的文献搜索.
包括的研究包括带有定量数据的RCT,准实验,队列和病例控制设计.
数据提取和质量评估是独立进行的,并使用随机效应模型进行元分析.

主要成果:

分析了45项涉及56787个卵子细胞的研究.
AOA在患者之前有受精失败的情况下显示了增加受精率的潜力.
没有观察到胚胎发育或临床结果的显著改善,包括活产率,特别是当排除低质量的研究或专注于RCT时.

结论:

AOA在特定的患者群体中显示了受精的潜在好处,这些患者有不良受精史.
证据不支持AOA在一般ICSI周期中增强胚胎发育或活产率.
这些发现强调了对证据质量的批判性评估对于指导辅助受孕临床实践的重要性.

关键词:

美国国务院调查局 (ICSI)卵细胞激活活动临床怀孕临床怀孕胚胎发育过程中的胚胎发育.肥料的使用方法这是一个元分析.

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