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溶液门薄膜晶体管生物传感器基于SnO₂无形膜用于无标签检测上皮细胞粘附分子

Yaxing Zhang¹, Zhiwei Cai¹, Rong Zou²

¹Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.

|January 31, 2025

概括

一种新的锡氧化物 (SnO2) 溶液通道薄膜晶体管 (SGTFT) 生物传感器被开发用于检测上皮细胞粘附分子 (EpCAM). 这种生物传感器为早期瘤诊断和健康监测提供了高灵敏度和特异性.

科学领域:

材料科学与工程材料科学与工程
纳米技术纳米技术
生物医学工程生物医学工程
生物传感器技术技术

背景情况:

表皮细胞粘附分子 (EpCAM) 是各种瘤的重要生物标志物,对于早期诊断和治疗至关重要.
金属氧化物半导体,特别是锡氧化物 (SnO2),由于其有利的性能和低成本,对生物传感器发展至关重要.
现有的生物传感方法需要提高灵敏度和特异性,以有效检测疾病.

研究的目的:

开发一种新的SnO2溶液通道薄膜晶体管 (SGTFT) 生物传感器,用于特定检测EpCAM.
为了优化SnO2膜的特性,以提高生物传感器性能.
建立一个高度敏感和特定的 EpCAM 检测平台,用于健康监测和疾病诊断.

主要方法:

使用SGTFT通道的sol-gel方法制造SnO2薄膜.
优化SnO2薄膜厚度 (100纳米) 以达到最佳的电特性 (gm = 1432μS,Vth = 0.288 V). 优化SnO2薄膜厚度 (100纳米) 以达到最佳的电特性 (gm = 1432μS,Vth = 0.288 V).
运用SnO2薄膜与aptamers进行特定的EpCAM识别和检测,通过网关电压调制.
使用FE-SEM,EIS,XPS和电性能测试进行表征.

主要成果:

优化的 SnO2-SGTFT 生物传感器显示出高检测灵敏度 (14.6 mV·dec−1).
实现了 EpCAM 的低检测极限 (LOD) 24.4 pg/mL.
已建立可靠的校准曲线,用于EpCAM度在0.02 ng/mL至500 ng/mL之间.

结论:

开发的SNO2-SGTFT生物传感器为EpCAM检测提供了一个高度敏感和特定的平台.
这项技术对推进健康监测和早期疾病诊断具有重大前景.
sol-gel方法和aptamer功能化是创建先进生物传感器件的有效策略.

关键词:

在 EpCAM 检测检测.在SnO2的基础上.生物传感器生物传感器电化学电化学电化学溶液入薄膜晶体管的薄膜晶体管是一个解决方案.溶凝方法 sol-gel 方法

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