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CD3/CD20/CD45 阴性白血病切割性

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概括
此摘要是机器生成的。

B-淋巴细胞白血病/淋巴瘤 (B-ALL/LBL) 很少表现为皮肤病变,即使在成年人中也是如此. 这一案例凸显了在不典型的皮肤表现中考虑B-ALL/LBL的重要性,特别是当常见的淋巴瘤标志物是负的时.

关键词:
B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL B-ALL/LBL皮切白血病 (Leukemia cutis) 是一种癌症.皮肤活检皮肤活检

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科学领域:

  • 血液学 血液学 血液学
  • 皮肤病学 皮肤病学
  • 在瘤学瘤学.

背景情况:

  • 乙型淋巴细胞白血病/淋巴瘤 (B-ALL/LBL) 通常影响儿童和年轻人.
  • 皮肤参与B-ALL/LBL并不常见.
  • 标准淋巴瘤标志物 (CD45,CD3,CD20) 在B-ALL/LBL中可能是负的.

研究的目的:

  • 报告一个罕见的成人发病B-ALL/LBL病例,呈现皮肤病变.
  • 强调B-ALL/LBL的非典型免疫表型所带来的诊断挑战.
  • 突出综合免疫组织化学在诊断罕见的血液性恶性瘤的重要性.

主要方法:

  • 在一个56岁的男性身上,多个柔软的皮肤病变的临床表现.
  • 皮肤穿孔活检显示了广泛的淋巴细胞透.
  • 免疫组织化学面板包括CD45,CD3,CD20,PAX5,TdT,CD10,CD34,CD79a,CD99等.
  • 周围血液和骨髓活检以确认.

主要成果:

  • 组织学和免疫类型发现证实了B-ALL/LBL.
  • 非典型的淋巴细胞透物对PAX5,TdT,CD10,CD34,CD79a和CD99.9呈阳性.
  • 这种透物对CD45,CD3,CD20,CD4,CD8,克拉,S100,CD56,CD138和EMA都是负的.
  • 外周血液和骨髓评估支持了诊断.

结论:

  • 即使在成年患者中,B-ALL/LBL也可以呈现为皮肤病变.
  • 对常见淋巴瘤标记物 (CD45,CD3,CD20) 的负染色不应排除B-ALL/LBL.
  • 这一案例强调了在白血病/淋巴瘤异常呈现时需要进行彻底的诊断工作的必要性.