关于失眠与客观短睡眠持续时间表型和高血压之间的关联的多omics研究
Yanyuan Dai1,2,3, Alexandros N Vgontzas4, Le Chen1,2,3
1Department of Sleep Medicine, Shantou University Mental Health Center, Shantou, Guangdong, China.
Sleep
|January 31, 2025
概括
慢性失眠障碍 (CID) 中睡眠时间短暂与高血压有关. 作为血清代谢物之一的硫酸,与血压和肠道细菌相关,这表明它可能会调解这种风险.
科学领域:
- 睡眠医学 睡眠医学
- 心血管健康 心血管健康
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 慢性失眠障碍 (CID) 的客观短睡眠时间是高血压的已知危险因素.
- 连接睡眠短暂与高血压的潜在机制仍然不完全理解.
研究的目的:
- 调查CID患者客观短睡眠时间与高血压之间的多组机制.
- 为了确定与睡眠时间短和高血压相关的特征代谢物和肠道微生物群.
主要方法:
- 利用多睡眠学来定义基于总睡眠时间的客观短睡眠时间.
- 使用血清代谢和便16SrDNA测序来分析代谢概况和肠道微生物群组成.
- 在患有慢性肺炎和正常睡眠患者中评估缩 (SBP) 和腹压 (DBP) 血压.
主要成果:
- 确定了52种与客观短睡眠时间失眠表型 (ISSD) 相关的血清代谢物.
- 在ISSD患者中发现血清氧硫酸与SBP和DBP正相关.
- 观察到氧硫酸含量与特定肠道细菌属 (Prevotella 9,CAG-56,Ruminiclostridium 9,Ruminococcus 2) 之间存在显著的相关性.
结论:
- ISSD表型的特点是血清代谢概况发生变化,特别是氧硫酸的含量升高.
- 硫酸可以作为一个分子链接之间的睡眠时间短,肠道微生物群的变化,并增加高血压的风险在CID.
- 对氧硫酸的进一步研究可能会揭示失眠中高血压的新型治疗点.
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