确定青少年和年轻成年人对瘤学症状管理临床试验参与的偏好
Robert Knoerl1, Liat Smener, Katherine Grandinetti
1Author Affiliations: Department of Health and Clinical Sciences, University of Michigan School of Nursing (Dr Knoerl and Mss Smener and Grandinetti); Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School (Drs Fecher, Henry, Karimi, Pettit, and Schuetze); Pediatric Hematology/Oncology, C.S. Mott Children's Hospital (Dr Walling); and School of Social Work, University of Michigan (Dr Zhang), Ann Arbor; and College of Nursing, The University of Tennessee, Knoxville (Dr Barton).
青少年和年轻成人癌症幸存者更喜欢临床试验,负担较低,副作用轻微. 让他们参与研究主题的选择,有助于他们参与症状管理研究.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 青少年和年轻人的健康 (AYA)
背景情况:
- 关于青少年和年轻成年人 (AYA) 参与临床试验的先前研究集中在外部因素上.
- 对AYA对试验设计和症状管理研究的具体偏好了解有限.
研究的目的:
- 确定AYA癌症幸存者的参与瘤症状管理临床试验的偏好.
- 确定影响AYA参与的关键属性和水平.
主要方法:
- 混合方法研究采用半结构面试和联合分析 (n=19).
- 基于选择的联合分析调查 (n=52) 以量化属性重要性和实用性得分.
- 用于实用性评分分析的等级贝叶斯估计.
主要成果:
- 最重要的属性是新治疗的类型 (22.9%) 和研究主题 (19.5%) 的感知重要性.
- 高度首选的水平包括轻微副作用的处方治疗,电子调查,短期访问 (<30分钟),没有后续,持续4周,每周治疗频率.
- 这些发现突出了对减少参与者负担和可管理的干预措施的偏好.
结论:
- 具有较低参与者负担和副作用较少的干预措施的临床试验设计吸引了AYA.
- 让AYA参与优先考虑研究主题对于加强他们参与症状管理试验至关重要.
- 结果可以指导临床医生在设计和招募AYA进行临床试验.
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