扫描源可见光光学连贯性断层扫描,可见光光学连贯性断层扫描
Optics letters
|January 31, 2025
概括
我们通过转换近红外激光器开发了扫描可见光源光学相干断层扫描 (SS-vs-OCT). 这种新的SS-vs-OCT成像为生物组织可视化提供了更深的深度和更好的性能.
科学领域:
- 生物医学光学 生物医学光学
- 光学成像技术的成像
- 激光技术 激光技术 激光技术
背景情况:
- 可见光光学连贯性断层扫描 (vis-OCT) 为高分辨率成像提供了潜力.
- 现有的光谱域对OCT系统在成像深度和信号滚动方面存在局限性.
研究的目的:
- 为了证明扫描源可见光光学连贯性断层扫描 (SS-vs-OCT) 的可行性.
- 与光谱域对OCT相比,改进成像深度和信号滚动.
主要方法:
- 采用了用于第二和生成 (SHG) 的周期极化酸 (PPLN) 晶体.
- 将近红外扫描源 (NIR-SS) 激光器转换为可见光SS激光器,通过助推光学放大器 (BOA) 放大,以实现580μW功率.
- 使用3D打印的金字塔幻影验证性能,通过扫描电子显微镜 (SEM) 进行交叉验证的测量.
主要成果:
- 在空气中达到7.3微米 (5.4微米在组织中) 的最大轴分辨率.
- 在空气中达到5毫米的成像深度 (在组织中达到3.7毫米).
- 与光谱域对OCT相比,成像深度增加了2.2倍,滚动率提高了2.8倍.
结论:
- 扫描可见光源OCT (SS-vs-OCT) 是可行的,并且比现有方法提供了显著的优势.
- 开发的SS-vis-OCT系统为高分辨率可视化提供了增强的成像深度和更好的性能.
- 这项技术对先进的生物医学成像应用具有前景.
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