尿路微生物组与糖尿病和糖尿病病相关:系统性审查
Tiscar Graells1, Yi-Ting Lin1,2, Shafqat Ahmad3,4,5
1Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institute, Huddinge, Stockholm, Sweden.
PloS one
|January 31, 2025
概括
尿路微生物组 (urobiome) 在糖尿病和糖尿病病患者中显示出减少的多样性. 了解骨干组对于监测糖尿病患者脏健康至关重要.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 转基因组学是指转基因组学.
背景情况:
- 尿路微生物组或尿管组是一个新兴的研究领域,它挑战了长期以来人们认为尿液是无菌的信念.
- 有限的数据存在于多多组合在健康和疾病,特别是关于其对糖尿病和随后的损伤的影响.
研究的目的:
- 系统地审查有关糖尿病和糖尿病病患者的多巴组的现有文献.
- 建立对尿路微生物组在糖尿病相关脏疾病中的作用的基线知识.
主要方法:
- 进行了对电子数据库的系统审查,搜索截至2024年11月.
- 选择了18项研究,包括各种设计,包括横截面和纵向研究.
- 16S rRNA测序是用于分析1571名参与者的多巴基因组的主要方法.
主要成果:
- 该审查分析了1571人的数据,包括糖尿病患者,糖尿病前期患者,糖尿病病患者和健康对照者.
- 一个值得注意的发现是,与健康对照人群相比,糖尿病患者尿道微生物群的丰富性和α-多样性下降.
- 随着病的进展,无论其原因如何,阿尔法多样性的进一步下降都被观察到.
结论:
- 这一系统性审查为糖尿病的背景下,提供了尿路微生物组的基础知识.
- 患有糖尿病的个体表现出尿路微生物群多样性的改变,其特点是丰度和α-多样性减少.
- 这些发现突显了多巴组分析在评估和监测糖尿病病进展方面的潜力.
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