在有抑郁症或没有抑郁症的通用焦虑症中,白质完整性的共同和独特变化
Huan Zhou1, Hailong Li1, Shiyu Liu2
1Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Journal of psychiatric research
|January 31, 2025
概括
通用焦虑症 (GAD) 白质 (WM) 变化在纯GAD和患有重大抑郁症 (MDD) 的GAD患者中都很明显. 显著的WM变化在体和上纵上是MDD的GAD的特征.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 通用焦虑症 (GAD) 是常见的,通常与严重抑郁症 (MDD) 一起发生.
- 白质 (WM) 完整性对大脑通信至关重要,并与GAD有关.
- 在MDD和没有MDD的GAD中,特定的WM异常尚未完全理解.
研究的目的:
- 与健康对照组 (HCs) 相比,研究纯GAD (p-GAD) 和GAD与MDD (GAD + MDD) 患者的WM微结构差异.
- 为了使用由底层解剖学 (TRACULA) 制约的通道进行详细的WM通道图.
- 为了将WM完整性与临床症状严重程度相关联.
主要方法:
- 招募了20名p-GAD,14名GAD+MDD患者和41名HC患者.
- 所有参与者获得T1MRI和扩散张力成像 (DTI).
- 使用TRACULA追踪了42个全脑WM纤维束,分析了体积,FA,MD,RD和AD. 进行了群组比较和相关性分析.
主要成果:
- 两组p-GAD和GAD + MDD都在左上纵向 (SLF) II和右环束 (CBD) 中显示了减少的分数异构 (FA).
- GAD + MDD患者在FA中表现出额外的减少,并且在体 (CC-BODY) 和右SLF I和II中平均扩散率 (MD) 和辐射扩散率 (RD) 增加.
- 在GAD+MDD患者中,症状严重程度与FA负相关,与RD正相关.
结论:
- 在p-GAD和GAD+MDD的左SLF和右CBD中发现了共享的WM中断.
- 在CC-BODY和右SLF中明显的WM变化是GAD + MDD患者的特征.
- TRACULA有效地描述了WM异常,突出了GAD与并发性MDD和没有并发性MDD的共同和独特模式.
相关概念视频
Generalized Anxiety Disorder
45
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
45
Anxiety: Overview
239
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
239
Stress and Mental Health
71
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
71
Panic Disorder
29
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
29
Alzheimer's Disease: Overview
437
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
437


