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Updated: May 30, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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柱子的长度仍然重要吗? 一个关于列长对治疗性寡核酸的分辨率的影响的案例研究

Dwight R Stoll1, Ajit Ghimire1, Matthew J Sorensen2

  • 1Department of Chemistry, Gustavus Adolphus College, Saint Peter, Minnesota, 56082, USA.

Journal of chromatography. A
|January 31, 2025
PubMed
概括

治疗性寡核酸 (ON) 的分析方法至关重要. 这项研究表明,虽然在恒定梯度斜率下,ON分辨率随着列长的增加而增加,但如果梯度斜率没有优化,它可以减少,从而影响方法的开发.

关键词:
柱子长度 柱子长度离子配对反向相位的离子配对.有氧核酸的部分.酸硫酸酸盐的使用方法决议 决议 决议

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