禁食和炎症挑战对猪肝脏代谢组的影响
Andrea N Gomez1, Bruce R Southey1, Maria B Villamil2
1Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
概括
禁食和炎症对男性和女性的肝脏代谢有不同的影响. 了解这些特定于性别的代谢变化对于开发有针对性的治疗来恢复两性肝脏健康至关重要.
科学领域:
- 代谢学 代谢学 代谢学
- 肝病学 肝病学是一种肝病学.
- 系统生物学 系统生物学
背景情况:
- 肝脏对环境压力因素做出反应,但研究往往侧重于单一的压力因素或性别.
- 肝脏对营养和炎症挑战的反应是复杂的,取决于性别.
研究的目的:
- 为了表征性质的肝脏代谢组变化,以应对禁食和病毒模拟诱导的炎症.
- 以性别特定的方式识别受这些压力因素影响的分子途径和代谢物.
主要方法:
- 非向液体染色学-质谱学 (LC-MS) 用于猪肝代谢组分析.
- 通过压力对性别相互作用的分析,以确定差异化的代谢物丰度和丰富的途径.
主要成果:
- 禁食和Poly (I:C) 诱导的炎症以性别特定的方式改变了肝脏新陈代谢.
- 关键受影响的途径包括跨膜传输,尿素循环,G蛋白合受体信号传递,葡萄糖平衡和维生素代谢.
- 对于肌酸,氨酸,甘氨酸衍生物,S-adenosylmethionine,histidine,甘氨酸和乳酸,观察到性别特异的代谢物差异.
结论:
- 24小时的禁食和轻度炎症显著调节肝脏新陈代谢.
- 代谢障碍在性别之间有所不同,这突显出需要针对肝脏平衡的性别特异性治疗策略.
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