富含奇数链脂肪酸的脂肪改善了牛奶替代剂养小猪的生长和肠道形态和功能
Geyan Duan1, Mengmeng Li2, Changbing Zheng3
1Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China; University of Chinese Academy of Sciences, Beijing, China.
The Journal of nutrition
|January 31, 2025
概括
牛奶替代品中的奇链脂肪酸 (OCFA) 显著改善了小猪的生长和肠道健康. 这些OCFA增强了平均每日收益和肠道形态,反映了母猪奶的好处.
科学领域:
- 动物营养 动物营养
- 胃肠病学 胃肠病学
- 发展生物学 发展生物学
背景情况:
- 小猪肠道的发育与人类婴儿的需要相似.
- 替代牛奶对小猪和婴儿的早期营养至关重要.
研究的目的:
- 评估各种奇链脂肪酸 (OCFA) 对小猪生长的影响.
- 评估OCFA对替代牛奶养的小猪肠道形态和功能的影响.
- 用小猪作为婴儿营养研究的模型.
主要方法:
- 40只7天大的小猪被分成五组.
- 群体接受了母猪牛奶或含有不同类型脂肪的牛奶替代品,持续21天.
- 统计分析包括ANOVA和未配对的t测试.
主要成果:
- 富含OCFA的替代牛奶增加了小猪的平均每日增益 (ADG).
- 观察到提升了的高度与密室深度的比率以及关键蛋白质表达 (Ki67,p-mTOR,p-S6K1,Occludin,Claudin,ZO-1).
- 观察到p-ULK1,Parkin和PINK1的蛋白质表达减少,类似于母猪奶养的小猪.
结论:
- 富含OCFA丰富脂肪的牛奶替代品可以促进小猪的生长.
- OCFA改善了肠道形态和功能,达到与母猪奶相当的水平.
- 这突显了OCFA在婴儿营养模型中的潜力.
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