抑郁症中的并发性焦虑和rTMS治疗反应:一项回顾性研究
Reza Kazemi1, Reza Rostami2, Mehdi Rezaei3
1Faculty of Entrepreneurship, University of Tehran, Tehran, Iran.
Journal of affective disorders
|January 31, 2025
概括
焦虑症状会影响抑郁症中重复性跨脑磁刺激 (rTMS) 反应. 身体焦虑预测反应较低,而主观焦虑预测单极和双极抑郁障碍的反应较高.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 关于焦虑对单极抑郁障碍 (UDD) 和双极抑郁障碍 (BDD) 重复性跨磁刺激 (rTMS) 疗效的影响的研究有限.
- 伴随性焦虑在UDD和BDD中很常见,可能会影响治疗结果.
研究的目的:
- 调查UDD和BDD患有并发性焦虑症患者的焦虑症状和rTMS反应之间的相关性.
- 评估rTMS在缓解抑郁和焦虑症状,包括特定焦虑亚型中的有效性.
主要方法:
- 总共有379名门诊患者 (214名UDD,165名BDD) 接受了20次单侧或双侧rTMS治疗,针对脊侧前额皮层 (DLPFC).
- 贝克焦虑清单 (BAI) 和贝克抑郁清单 (BDI-II) 进行了症状评估.
主要成果:
- 治疗前的身体焦虑得分与rTMS反应有负相关性,而主观焦虑得分显示出正相关性.
- 在UDD和BDD患者中观察到基于焦虑症状的独特反应概况.
- 这两种rTMS协议都显著减少了抑郁,身体焦虑,主观焦虑和与恐慌相关的焦虑症状.
结论:
- 身体焦虑症状与rTMS反应的减少有关,而主观焦虑症状表明在UDD和BDD中都有更好的反应.
- 焦虑症状的亚型可以作为预测标记,用于在患有并发性焦虑症的患者中预测rTMS治疗结果.
- 需要进一步的前性研究来验证这种患者群体中焦虑症状的预测价值.
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