纤维素的希夫基:合成,表征和抗癌效应对肝细胞癌
El-Refaie Kenawy1, Heikki Tenhu2, Mohamed M Azaam1
1Polymer Research Group, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
International journal of biological macromolecules
|January 31, 2025
概括
新型纤维素希夫基显示出强大的抗癌活性. 一种衍生物SB4通过增加氧化应激,有效地诱导肝癌细胞的细胞循环停止和细胞亡,提供了一种新的治疗策略.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 药用化学 医学化学
背景情况:
- 开发具有较少副作用的抗癌药物至关重要.
- 聚合物希夫基因由于其生物活性,特别是抗癌性质,显示出有前途的治疗潜力.
研究的目的:
- 合成来自微晶纤维素的新型希夫基.
- 评估这些基于纤维素的希夫基对各种癌症细胞系的抗癌疗效.
主要方法:
- 纤维素被氧化成二甲纤维素 (DAC).
- DAC与高分支聚乙烯胺 (hPEI) 接种,形成氨基化纤维素.
- 希夫基通过将hPEI纤维素与各种化物反应而合成,并使用光谱和热方法进行表征.
主要成果:
- 合成的纤维素希夫基表明显著抑制癌细胞生长.
- 一种特定的衍生物,SB4 (含有三甲甲),在肝细胞癌 (Hep G2) 细胞中诱导细胞周期停止和细胞亡.
- SB4充当了亲氧化剂,增加了活性氧物种和氧化应激,同时降低了Hep G2细胞中的抗氧化系统.
结论:
- 基于纤维素的希夫基是开发抗癌药物的有希望的新战略.
- 由于其诱导亡和氧化应激的能力,SB4显示出作为肝癌治疗的治疗剂的潜力.
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