在固体器官移植中肺性免疫性损害
Elizabeth A Lendermon1, Chadi A Hage2
1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh Medical Center, 3459 Fifth Avenue, MUH NW 628, Pittsburgh, PA 15213, USA.
Clinics in chest medicine
|January 31, 2025
概括
固体器官移植接受者由于免疫功能障碍而面临肺部感染风险增加. 本综述详细介绍了免疫抑制剂及其作用以及评估免疫抑制水平的方法.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 固体器官移植接受者容易发生免疫功能障碍.
- 肺部感染在这个患者群体中构成重大风险.
- 了解免疫抑制对于管理移植结果至关重要.
研究的目的:
- 审查导致免疫功能障碍和移植受体肺部感染风险的因素.
- 解释免疫抑制剂的机制并比较免疫抑制剂的临床作用.
- 讨论评估免疫抑制净状态的方法及其局限性.
主要方法:
- 临床科学报告的文献综述.
- 解释免疫抑制剂的机制.
- 免疫抑制药物的临床效应的比较.
- 讨论免疫抑制的专业评估方法.
主要成果:
- 多种因素导致免疫功能障碍和移植后感染风险.
- 免疫抑制剂的机制和临床效果各不相同.
- 评估净免疫抑制的方法存在,但有局限性.
结论:
- 对固体器官移植接受者来说,对免疫抑制的全面了解至关重要.
- 管理免疫功能障碍可以减轻肺部感染风险.
- 对精确免疫抑制评估的进一步研究可能会改善患者的护理.
相关概念视频
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Immunodeficiency Diseases
895
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
895
Cell-mediated Immune Responses
66.7K
Overview
66.7K
Tissue Transplantation
332
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
332
Pneumonia I: Introduction
205
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
205
Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K


