人类免疫缺陷病毒疾病中的肺免疫性损害
Engi F Attia1, Elizabeth Maleche-Obimbo2, Laura E Ellington3
1Division of Pulmonary, Critical Care and Sleep Medicine, Departments of Medicine and Global Health, University of Washington School of Medicine, Seattle, WA, USA.
Clinics in chest medicine
|January 31, 2025
概括
人类免疫缺陷病毒 (HIV) 感染者的肺病已经转变为慢性疾病. 本综述涵盖了当前的流行病学,风险因素和与艾滋病毒相关的肺部疾病的临床护理建议.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 艾滋病毒/艾滋病研究研究
背景情况:
- 人类免疫缺陷病毒 (PWH) 患者的肺病谱已经发展.
- 从急性,传染性和艾滋病定义疾病转向慢性,非传染性肺部疾病.
- 当代抗逆转录病毒疗法 (ART) 时代对PWH肺部健康的影响.
研究的目的:
- 在整个生命周期中审查PWH肺部疾病的流行病学.
- 在ART时代确定PWH肺部疾病的关键风险因素.
- 提供PWH肺部疾病的临床护理建议,包括最近的试验数据.
主要方法:
- 对流行病学数据的文献综述.
- 在当前艾滋病毒治疗的背景下分析风险因素.
- 从最近和正在进行的临床试验中综合发现.
主要成果:
- 肺部疾病在PWH中越来越多地以慢性,非传染性过程为特征.
- 抗逆转录病毒疗法改变了与艾滋病毒相关的肺部疾病的格局.
- 新出现的数据突出显示,需要更新临床管理策略.
结论:
- 在PWH肺病的管理需要专注于慢性疾病.
- 了解不断变化的风险因素对于PWH肺部健康至关重要.
- 临床护理必须适应正在进行的研究和试验的新证据.
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