在2016年至2022年期间,在奥迪沙邦布巴内斯瓦尔的结核性脑膜炎
Chinmayee Mohanty1, Triyambakesh Mohanty1, Sarita Kar1
1ICMR-Regional Medical Research Centre, Bhubaneswar, 751023, Odisha, India.
The Indian journal of tuberculosis
|January 31, 2025
概括
结核性脑膜炎 (TBM) 影响了许多位置,通过基于盒子的核酸放大测试 (CBNAAT) 改善了诊断. 这项研究在CSF样本中发现了3.1%的M.结核病阳性率,在Bhubaneswar,Odisha的Rifampicin耐药性为6%.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核性脑膜炎 (TBM) 负担在地理上有所不同,受当地结核病患病率和人口年龄结构的影响.
- 传统的诊断方法,如酸快细菌 (AFB) 涂抹和TBM培养,在灵敏度和速度上都有局限性.
- 快速分子方法,如基于弹药的核酸放大测试 (CBNAAT),为TBM诊断提供了更好的灵敏度和速度.
研究的目的:
- 为了评估结核病的负担和怀疑结核性脑膜炎病例的里法辛耐药性. 在Bhubaneswar, Odisha.
- 评估CBNAAT在特定地理区域诊断结核性脑膜炎的有用性.
- 分析通过CBNAAT测试的假定TBM患者的人口统计和实验室数据.
主要方法:
- 从2016年2月到2022年12月,在布巴内斯瓦尔的国家参考实验室 (NRL) 使用CBNAAT测试的大脑脊髓液 (CSF) 样本的回顾性分析.
- 数据收集包括人口统计信息,M.结核病阳性和抗利芬素耐药性.
- 对年龄和性别分布,推来源和阳性率的统计分析.
主要成果:
- 总共分析了来自假定TBM患者的1627个CSF样本.
- 3.1% (50/1627) 的样本使用CBNAAT.检测出M.结核病阳性.
- 6% (3/50) 的M.结核病阳性样本表现出对利芬素的耐药性,阳性因年龄组和年龄而异.
结论:
- 在约7年的时间里,CBNAAT从疑似TBM病例的CSF样本中确定了3.1%的M.结核病阳性率.
- 鉴定到的M.结核病菌株中,很大一部分 (6%) 对利法皮辛有抗性.
- 建议对奥迪沙的更多地区进行进一步的研究,以确定该州的TBM的全面流行率.
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