挥发性有机化合物与美国青少年功能之间的关系:三个统计模型
Jiaqi Zhang1, Runhong Li1, Kaiyuan Wang1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.
International journal of environmental health research
|January 31, 2025
概括
青少年中挥发性有机化合物 (mVOC) 的尿液代谢物与功能标志物有显著的关联. 暴露于mVOCs可能会影响估计的膜过率 (eGFR) 和其他脏参数.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢学 代谢学 代谢学
背景情况:
- 挥发性有机化合物 (mVOCs) 的尿液代谢物是新兴的生物标志物.
- 青少年的功能对长期健康至关重要.
- 了解环境暴露及其对脏健康的影响至关重要.
研究的目的:
- 调查17种尿路mVOC与青少年关键功能参数之间的关系.
- 评估mVOC混合物对脏健康的综合影响.
主要方法:
- 使用通用线性模型 (GLM) 来分析个别的mVOC关联.
- 员工加权四分位数总和 (WQS) 指数用于评估混合效应.
- 应用贝叶斯核机器回归 (BKMR) 进行综合混合物分析.
- 测量脏参数,包括估计的淋巴膜过率 (eGFR),专蛋白与肌素的比率 (ACR),尿蛋白,血清尿酸 (SUA) 和血液尿素 (BUN).
主要成果:
- 个别的mVOC与eGFR,尿蛋白和BUN.UN显著正相关.
- 在mVOCs和ACR和SUA之间观察到负相关性.
- 在WQS指数显示了与eGFR,尿蛋白,SUA和BUN的显著关联.
- BKMR模型显示了总化合物效应和eGFR之间的正相关性,混合物的高度与尿蛋白和ACR的增加有关.
结论:
- 单次和混合暴露于尿路mVOCs都与青少年功能参数的改变有关.
- 这些发现凸显了mVOC暴露对青少年脏健康的潜在影响.
- 需要进一步的研究来阐明机制和长期后果.
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