腹侧前额皮层中的高β功率指数人类的接近行为:一个案例研究
Nicole R Provenza1,2, Sameer V Rajesh1, Gabriel Reyes1
1Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
概括
强迫症 (OCD) 的深度大脑刺激 (DBS) 可能会增加接近行为. 腹侧前额皮层 (vlPFC) 的高β功率与DBS期间的语音速率相关,这表明它.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经调节是一种神经调节.
背景情况:
- 腹腔囊和腹腔条纹体 (VC/VS) 的深度大脑刺激 (DBS) 有效地治疗抗性强迫症 (trOCD).
- 启动DBS可以急剧改善情绪和能量,从而增加社会参与和谈话力,称为"接近行为".
研究的目的:
- 调查VC/VS DBS期间接近行为的神经生理基础.
- 探索刺激振幅,腹侧前额皮层 (vlPFC) 谱电力和trOCD患者的言语速率之间的关系.
主要方法:
- 慢性内记录从vlPFC和轨道前皮层 (OFC) 在一个男性患者的trOCD接受VC/VS DBS.
- 实验比较神经生理学数据和17周的高与低振幅刺激时代的语音速率.
- 分析高贝塔频段 (31±1.5Hz) 和语音频率的光谱功率,并对语音对神经活动的影响进行特定测试.
主要成果:
- 在高振幅刺激期间,与低振幅期间相比,语音速率和vlPFC高β功率显著增加.
- 发言速度和vlPFC高β功率之间观察到正相关性,特别是在左半球.
- 语音本身,没有刺激变化,并没有提高vlPFC高β功率,表明刺激是主要的驱动因素.
结论:
- 腹侧前额皮层 (vlPFC) 的高β功率可以作为VC/VS DBS诱导的接近行为潜在的生物标志物.
- 这种神经信号可能代表从适应性方法行为到不适应性躁狂症状的连续性,需要进一步调查.
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