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相关概念视频

Histology of the Small Intestine01:27

Histology of the Small Intestine

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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
448
Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Large Intestine01:09

Large Intestine

391
The large intestine is divided into three main regions: the cecum, colon, and rectum. Extending from the ileocecal valve to the anus, it frames the small intestine on three sides.
The ileocecal sphincter, a mucous membrane fold, guards the opening from the ileum to the large intestine. This valve permits material from the small intestine to pass into the large intestine. Attached to the ileocecal valve is the cecum. This small pouch, approximately 6 cm long, has a twisted, coiled tube known as...
391
Digestive Functions of the Large Intestine01:20

Digestive Functions of the Large Intestine

335
The large intestine is where the final stages of digestion happen. When the cecum receives chyme, it contains undigested carbohydrates that undergo fermentation. Gut bacteria ferment these carbohydrates to produce short-chain fatty acids that provide some energy and help synthesize essential vitamins.
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
335
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

172
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
172
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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相关实验视频

Updated: May 29, 2025

A Mouse Model of Intestinal Partial Obstruction
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小肠变化,大肠问题.

Deepanshu Singla1, Abigail E Rose1, Wenhan Zhu1

  • 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Trends in microbiology
|January 31, 2025
PubMed
概括
此摘要是机器生成的。

沙门氏菌的入侵破坏了肠道氨基酸的吸收,增加了大肠中的可用性. 这通过改变微生物新陈代谢和克服宿主防御来推动病原体的殖民.

关键词:
沙门氏菌是一种沙门氏菌.殖民化 抵抗 抵制短链脂肪酸 短链脂肪酸

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Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
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科学领域:

  • 微生物学 微生物学
  • 胃肠病学 胃肠病学
  • 病原体与宿主相互作用

背景情况:

  • 肠道病原体面临着来自肠道微生物群的殖民抵抗.
  • 了解病原体适应策略对于控制感染至关重要.

研究的目的:

  • 为了研究沙门氏菌如何适应入侵后的肠道环境.
  • 阐明沙门氏菌用于殖民肠道的代谢机制.

主要方法:

  • 这项研究分析了沙门氏菌入侵对小肠道营养吸收的影响.
  • 研究了大肠中氨基酸的代谢命运.

主要成果:

  • 沙门氏菌侵入小肠,导致显著的氨基酸吸收不良.
  • 在大肠中增加光线氨基酸的可用性,支持沙门氏菌的生长.
  • 沙门氏菌利用氨基酸脱碳,抵消短链脂肪酸诱导的酸化.

结论:

  • 沙门氏菌积极操纵宿主营养吸收以促进自己的殖民.
  • 代谢适应,包括氨基酸脱碳化,是沙门氏菌克服宿主防御的关键.