在大型动物模型中,关节退化的分子机制
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Updated: Jul 25, 2026

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J L G C Monteiro1, Y M Sillmann1, T M Kambakhsh2
1Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
International journal of oral and maxillofacial surgery
|January 31, 2025
概括
本综述总结了关节退行性疾病 (TMJ-DD) 的大型动物模型中的分子机制. 研究结果有助于制定有针对性的策略,以防止关节疾病的进展.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 分子生物学分子生物学
- 生物医学工程 生物医学工程
背景情况:
- 关节退行性疾病 (TMJ-DD) 影响关节健康.
- 了解分子机制对于有效治疗至关重要.
- 大型动物模型为TMJ-DD提供了宝贵的见解.
研究的目的:
- 系统地审查研究TMJ-DD分子机制的大型动物模型.
- 确定与TMJ-DD相关的关键生物标志物.
- 为开发新型治疗策略提供信息.
主要方法:
- 在PubMed/MEDLINE,Embase和Cochrane图书馆数据库中进行全面的文献搜索.
- 包括2024年4月之前发表的英语研究.
- 独立的文章选择和数据提取由两个评论员,与高级作者仲裁.
- 评估ARRIVE准则对报告标准的遵守情况.
主要成果:
- 七项研究符合纳入标准:三项用于绵羊,两项用于马,两项用于猪.
- 确定了与TMJ-DD病原体相关的生物标志物.
- 总结了关节退化所涉及的分子途径.
结论:
- 大型动物模型提供了关于TMJ-DD分子支柱的重要数据.
- 已识别的标记物可以指导开发有针对性的,最少侵入性干预措施.
- 使用这些模型进行进一步的研究可以促进TMJ-DD的预防和治疗.
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