Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Local and circulating cytotoxic CD4⁺ T cells are early markers of disease activity in pediatric Crohn's disease.

medRxiv : the preprint server for health sciences·2026
Same author

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease.

bioRxiv : the preprint server for biology·2026
Same author

Spatial transcriptomics identifies immune-stromal niches associated with cancer in adult dermatomyositis.

Nature communications·2026
Same author

Coordinated immune-epithelial dynamics in the nasal epithelium protect against respiratory virus infection.

bioRxiv : the preprint server for biology·2026
Same author

Aging disrupts spatiotemporal coordination in the cycling murine ovary.

Nature aging·2026
Same author

Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors.

Nature biotechnology·2026
Same journal

Large-scale discovery and annotation of substructure patterns in mass spectrometry profiles.

Nature communications·2026
Same journal

Salmonella SopB suppresses post-transcriptionally regulated cytokine release to reduce early tissue inflammation and delay disease progression.

Nature communications·2026
Same journal

A human-specific microRNA controls the timing of excitatory synaptogenesis.

Nature communications·2026
Same journal

An HMA-like integrated domain in the wheat tandem kinase WTK4 recognises an RNase-like pathogen effector.

Nature communications·2026
Same journal

Learning regularities in noise engages both neural predictive activity and representational changes.

Nature communications·2026
Same journal

The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers.

Nature communications·2026
查看所有相关文章

相关实验视频

Updated: Jun 13, 2026

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
09:31

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

7.8K

在肠道组织微环境中进行宿主微生物组剖析的多omics空间框架.

Bokai Zhu1,2,3, Yunhao Bai2,3, Yao Yu Yeo4

  • 1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

Nature communications
|January 31, 2025
PubMed
概括
此摘要是机器生成的。

微生物组绘图 (MicroCart) 提供了一种新的方法,可以在现场研究宿主微生物组相互作用. 这种空间的多组学框架揭示了在肠道炎症期间的动态免疫和微生物转移.

更多相关视频

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.2K
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.0K

相关实验视频

Last Updated: Jun 13, 2026

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
09:31

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

7.8K
An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.2K
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.0K

科学领域:

  • 微生物组研究的研究.
  • 主体微生物群的相互作用
  • 空间的多态学.

背景情况:

  • 主体免疫系统和微生物群的相互作用是动态的,随着肠道环境的变化而发生变化.
  • 目前的现场方法限制了对宿主和微生物群落的同时,系统级研究.
  • 了解这些相互作用对于研究肠道健康和疾病至关重要.

研究的目的:

  • 介绍微生物组绘图 (MicroCart),这是一个新的框架,用于同时对宿主和微生物组进行现场探测.
  • 实现宿主微生物群相互作用的多模式空间分析.
  • 在小鼠结肠炎模型中调查宿主和微生物组的变化.

主要方法:

  • 开发了微生物组绘图 (MicroCart) 用于同时在现场的空间多态.
  • 应用MicroCart使用空间蛋白质组学,转录组学和糖组学.
  • 研究了一种小鼠结肠炎模型来分析肠道宿主和微生物组的变化.

主要成果:

  • 证明了MicroCart在现场同时进行宿主和微生物组分析的能力.
  • 揭示了结肠炎期间组织免疫反应的系统性转变.
  • 观察到细菌群体的变化,局部炎症和代谢变化.

结论:

  • MicroCart提供了一个强大的工具,用于对宿主微生物群相互作用进行深入,空间解析的调查.
  • 该框架使组织重塑和细胞反应的全面分析成为可能.
  • 促进对宿主组织和病态中的微生物群之间的复杂相互作用的理解.