与冠状动脉,大脑和动脉相比,对外围动脉疾病的风险因素概况的差异
Stefan Acosta1,2, Yufeng Du3,4, Yan Borné3
1Department of Clinical Sciences, Lund University, Ruth Lundskogs g 10, 205 02, Malmö, Sweden. Stefan.acosta@med.lu.se.
Scientific reports
|January 31, 2025
概括
吸烟和糖尿病显著地驱动了外周动脉疾病 (PAD) 比其他动脉疾病更多. 检查下肢动脉可能是高风险患者早期检测的关键.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 血管生物学 血管生物学
背景情况:
- 周围动脉疾病 (PAD) 与其他动脉样硬化的疾病 (如冠状动脉疾病 (CoAD),缺血性中风 (IS) 和动脉疾病 (CaAD) 具有共同的风险因素.
- 了解风险因素对PAD与其他动脉样硬化表现的相对贡献对于有效的预防策略至关重要.
研究的目的:
- 为了确定下肢外周动脉疾病 (PAD) 的主要驱动因素.
- 将PAD的病因驱动因素与冠状动脉,脑前动脉和脑动脉疾病的病因驱动因素进行比较.
主要方法:
- 前性队列研究 (马尔默饮食和癌症研究) 共有26,681名参与者.
- 经过验证的PAD,CoAD,IS (非心房) 和CaAD事件的确诊.
- 修改的Lunn-McNeil竞争风险分析和使用考克斯回归和直接方法估计人口归因风险分数 (PAF).
主要成果:
- 男性的性别,年龄和高血压是所有研究的动脉样硬化疾病的常见风险因素.
- 目前的吸烟是主要原因,占PAD风险的45.6%,而CoAD为16.1%,IS为14.0%,CaAD为23.3%.
- 吸烟和糖尿病与PAD发展的关联明显比CoAD,IS或CaAD更强,这表明对PAD的影响更大.
结论:
- 与其他主要动脉疾病相比,吸烟和糖尿病是发展PAD的不成比例的重要危险因素.
- 鉴于强烈的关联性和可访问性,检查下肢动脉可以作为患有广泛动脉样硬化风险的患者的初步诊断步骤.
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