透露危急状态并通过先进的分析方法在个体基础上识别2型糖尿病的个性化动态网络生物标志物
Peiyu Li1,2, Shaowen Jing3, Guo Tian3
1Network and Informatization Office, Henan University of Science and Technology, Luoyang, China. lpy@haust.edu.cn.
Scientific reports
|January 31, 2025
概括
识别疾病前的关键状态是具有挑战性的. 本研究介绍了三种数据驱动的方法:单样本詹森-香农分歧 (sJSD),网络信息获取 (NIG) 和时间网络流 (TNFE),以从单个样本中检测这些状态和动态网络生物标志物.
科学领域:
- 计算生物学是一种计算生物学.
- 系统生物学 系统生物学
- 生物医学数据科学是生物医学数据科学.
背景情况:
- 复杂疾病往往缺乏早期症状,通过正常,危急的疾病前期和疾病状态进展.
- 从单个样本中检测这些危急的疾病前状态是很困难的.
- 早期识别关键状态对于个性化疾病诊断和干预至关重要.
研究的目的:
- 评估三种新方法 (sJSD,NIG,TNFE) 在从单个样本中识别关键疾病前状态和动态网络生物标志物 (DNBs) 的有效性.
- 为了比较这些方法的灵敏度和稳定性.
- 为早期疾病检测提供数据驱动,无模型的方法.
主要方法:
- 在模拟数据和2型糖尿病数据集 (GSE13268,GSE13269) 中应用单个样本的詹森-香农分歧 (sJSD),网络信息获取 (NIG) 和时间网络流量 (TNFE).
- 使用不一致指数 (ICI),NIG和TNFE来衡量与参考样本相对的样本中断.
- 分析了这些指数的变化,以确定关键疾病状态并确定DNBs.
主要成果:
- 这三种方法在模拟和现实数据集 (如2型糖尿病) 中都成功检测出疾病前临界状态.
- 确定了关键状态的特定时间点,证明了检测恶化前阶段的能力.
- 展示了方法灵敏度的差异,sJSD更灵敏,NIG/TNFE更强大.
结论:
- sJSD,NIG和TNFE方法有效地使用单个样本数据识别关键状态和DNB.
- 这些数据驱动,无模型的方法为个性化疾病诊断提供了显著的潜力.
- 这些发现增强了对复杂疾病进展和临床实践见解的理解.
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