在超临界二氧化碳中含有和不含辅助溶剂的梅萨拉溶解度和建模
Seyed Ali Sajadian1,2, Nadia Esfandiari2, Adrián Rojas3,4
1Department of Chemical Engineering, Faculty of Engineering, University of Kashan, Kashan, 87317-53153, Iran.
Scientific reports
|January 31, 2025
概括
这项研究测量了在含有或不含辅助溶剂的超临界二氧化碳 (scCO2) 中的梅萨拉溶解度. 一个新的关联模型准确地预测了溶解度,显示了辅溶剂的性能改善.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 制药科学 制药科学
背景情况:
- 梅萨拉是一种重要的抗炎药物.
- 超临界二氧化碳 (scCO2) 为制药加工提供了一种绿色和可调节的溶剂.
- 了解mesalazine在scCO2中的溶解性对于优化药物配方和输送至关重要.
研究的目的:
- 为了确定mesalazine在scCO2中的溶解度,在各种温度 (308-338K) 和压力 (12-30MPa) 范围内.
- 为了研究辅溶剂 (二甲基硫氧化物) 对scCO2.中梅萨拉溶解度的影响.
- 开发和验证一种新的关联模型,用于预测scCO2二进制和三进制系统中mesalazine溶解度.
主要方法:
- 在不同温度和压力下,实验性地确定mesalazine在scCO2中的分子溶解度.
- 添加2%的二甲基硫氧化物作为辅溶剂,以研究其对溶解度的影响.
- 应用一种新的关联模型并与半实证相关性进行比较,以模拟可溶性数据.
主要成果:
- 梅萨拉在scCO2中的溶解度随着温度和压力而增加.
- 存在的二甲基硫氧化物显著提高了mesalazine在scCO2中的可溶性.
- 新的关联模型显示出卓越的准确性,平均绝对相对偏差为4.13% (没有辅助溶剂) 和3.36% (有辅助溶剂).
结论:
- 梅萨拉在scCO2中的溶解度高度依赖于温度,压力和辅溶剂的存在.
- 开发的关联模型为预测scCO2系统中mesalazine溶解度提供了一个可靠的工具.
- 这项研究有助于推进梅萨拉的绿色制药加工技术.
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