在慢性炎症疾病和癌症中训练有素的免疫力
George Hajishengallis1, Mihai G Netea2,3, Triantafyllos Chavakis4
1Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. geoh@upenn.edu.
Nature reviews. Immunology
|January 31, 2025
概括
训练免疫 (TRIM) 涉及免疫细胞中的表观遗传记忆,提供对感染的保护. 新兴研究揭示了TRIM.
科学领域:
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 具有天生的免疫力.
背景情况:
- 训练免疫 (TRIM) 描述了由于表观遗传记忆导致的长期的先天性免疫细胞高反应性.
- 最初被认为具有抗感染功效,但TRIM在更广泛的健康和疾病中的作用越来越被理解.
研究的目的:
- 审查TRIM对感染的有益影响.
- 讨论TRIM在慢性炎症疾病和癌症中的新兴作用.
- 探索针对TRIM的治疗策略.
主要方法:
- 文献综述和现有关于训练免疫力的研究综合.
- 分析证据,将TRIM与各种疾病和疾病联系起来.
- 基于当前的知识,讨论潜在的治疗应用.
主要成果:
- 对于感染,TRIM具有有益的作用.
- TRIM被认为是慢性炎症疾病的机制,如牙周炎,类风湿性关节炎和心血管疾病.
- TRIM诱导显示出保护性的抗瘤反应.
结论:
- TRIM具有双重作用,在感染和癌症中可能有益,但有助于慢性炎症疾病.
- 需要对TRIM机制进行进一步的研究.
- 调节TRIM (刺激或抑制) 的特定环境治疗策略对于癌症和炎症疾病等疾病是可行的.
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