开发和验证用于预测用CPB进行心脏手术的儿童外科手术后输血的诺姆图
Wenting Wang1,2, He Wang2, Jia Liu2
1Department of Anesthesiology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
BMC anesthesiology
|January 31, 2025
概括
一个新的模型准确地预测了儿科心脏手术患者的红细胞输血风险. 这种工具有助于个性化血液管理,为儿童进行心肺旁路手术.
科学领域:
- 儿科心脏手术 儿科心脏手术
- 输血医学 输血医学
- 临床预测建模临床预测建模
背景情况:
- 术后红细胞输血 (PRT) 风险评估对于儿童心脏外科手术中个性化血液管理至关重要.
- 开发准确的预测模型对于优化这种脆弱人群的护理至关重要.
研究的目的:
- 构建和验证在接受心肺旁路手术 (CPB) 心脏手术的儿科患者中PRT风险的预测模型.
主要方法:
- 一组23884名儿科患者被分为训练和测试组.
- 单变量,LASSO和多变量逻辑回归确定了PRT的关键预测因素.
- 开发了一个名图,并对其性能进行歧视,校准和临床实用性评估.
主要成果:
- 确定了八个预测因素:年龄,体重,血红蛋白,蓝色心脏病,CPB持续时间,最小直肠温度,CPB原始体积和切口类型.
- 该模型表现出强大的预测性能,AUC为0.886 (训练) 和0.883 (测试).
- 该模型显示了良好的校准和临床实用性.
结论:
- 开发的预测模型有效地评估了儿科心脏手术患者的PRT风险.
- 该工具为临床医生提供了一种实用的方法,以优化个性化的外科手术期间血液管理策略.
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