在非结核性菌根性肺病中死亡率和死亡原因
A A Pedersen1, V N Dahl2, A Løkke3
1Department of Medicine, Lillebaelt Hospital, Vejle, Denmark;, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark;, Mycobacterial Centre for Research Southern Denmark (MyCRESD), Odense, Denmark.
概括
患有非结核性菌根性肺病 (NTM-PD) 的患者面临显著更高的死亡率. 这项研究强调,迫切需要对NTM-PD及其相关呼吸道疾病给予更多关注.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 非结核性菌根性肺病 (NTM-PD) 的死亡率和死亡原因需要进一步调查,特别是在欧洲人群中.
- 关于NTM-PD结果的长期随访数据有限.
- 这项研究旨在确定NTM-PD是否与与对照组相比增加死亡率和不同的死亡原因有关.
研究的目的:
- 评估NTM-PD与全因死亡率之间的关联.
- 为了比较NTM-PD患者和匹配的对照组之间的死亡原因.
- 在NTM-PD中调查延长后续期的死亡模式.
主要方法:
- 利用丹麦国家登记册,在2000-2017年间识别NTM-PD患者.
- 匹配NTM-PD患者1:4与基于年龄,性别,同居状态和市镇的对照.
- 通过生存分析和比较统计数据分析死亡率和死亡原因.
主要成果:
- 确定了661名NTM-PD患者;5年死亡率为51%与对照组15%相比.
- 在NTM-PD患者中,死亡风险比率高3.1倍 (调整后HR为1.9).
- 呼吸系统疾病是NTM-PD患者 (45.2% vs 11.6%) 的更常见死亡原因,而真菌细菌感染直接导致5.8%的死亡.
结论:
- 与匹配的对照组相比,NTM-PD与较高的全因死亡率显著相关.
- 死亡风险增加在诊断后的最初几年特别明显.
- 这些发现强调了需要加强对NTM-PD和相关肺部疾病的临床关注.
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