结核病干预措施的集群随机试验中的污染影响
K E LeGrand1, K Allel2, P Khan3
1Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine (LSHTM), London, UK.
结核病 (TB) 干预的集群随机试验 (CRT) 显示出混合的结果,可能是由于污染. 需要改进报告和设计,以准确评估干预影响.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 临床试验 临床试验
背景情况:
- 对结核病 (TB) 干预的集群随机试验 (CRT) 产生不一致的结果.
- 由于人口流动,污染可能会稀释CRT的干预效应.
- 评估结核病干预措施对人口水平的影响需要仔细设计试验.
研究的目的:
- 系统地审查关于结核病干预CRT的文献.
- 确定影响CRT有效性和报告的因素.
- 为改善CRT设计和报告提供建议.
主要方法:
- 对结核病干预措施的CRT进行系统文献综述.
- 提取试验设计,干预,结果,人口和地理数据.
- 包括试验的描述性统计和空间分析.
主要成果:
- 在选了1039份摘要后,包括了7个CRT的20份报告.
- 集群的中位数是32;每个集群的人口范围在400-50,000之间.
- 报告的污染潜力不一致;设计局限性得到承认.
结论:
- 在CRT的方法和结果报告中存在差距.
- 对于CRT来说,需要标准化的报告工具.
- 建议改进CRT设计和报告实践,以准确测量结核病干预影响.
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