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临床实验室中酸盐污染的发生率和检测

Nathan Lorde¹, Rousseau Gama^1,2, Tejas Kalaria¹

¹Blood Sciences, Black Country Pathology Services, 8692 The Royal Wolverhampton NHS Trust , Wolverhampton, UK.

Clinical chemistry and laboratory medicine

|February 1, 2025

概括

在高纳血清中酸污染不常见,影响了3.1%的样本. 在大多数情况下,血清化物或化间隙查可以排除污染.

科学领域:

临床化学临床化学
实验室医学实验室医学
分析化学分析化学

背景情况:

由于酸盐 (Na3Citrate) 的污染,超血症可能是由虚假的结果引起的.
血清酸盐的直接测量是识别Na3酸盐污染的黄金标准.
间接标记器通常用于选潜在污染物.

研究的目的:

为了确定Na3Citrate污染在高纳特雷米血清样本中的流行率.
评估间接标记在识别Na3酸盐污染中的有效性.

主要方法:

在三个月内分析了含量≥148 mmol/L的血清样本.
直接酸盐测量被用作黄金标准.
评估了血清化物的性能,化差距,ISE差异和度差距.

主要成果:

27个被Na3酸盐污染的样本被确定 (3.1%的超纳特雷米样本).
污染在血液透析患者中最常见 (59.3%).
血清化物 (≤105 nmol/L) 和化差距 (≥47 mmol/L) 显示出检测污染的高特异性.

结论:

三酸污染很少见,但发生,特别是在血液透析患者.
血清化物和化间隙是有效的选工具,以排除污染.
在模两可的情况下,直接测量酸盐是必要的,以确定诊断.

关键词:

这是一个Citra锁.酸污染的污染情况酸盐锁定酸盐锁定错误检测检测错误检测错误检测错误检测错误检测错误检测错误检测错误检测样品污染的污染情况三酸酸盐的使用方法

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