用双端离心为双端循环支持的心房和心室通道:体外评估
Christine R Flick1, Chihiro Miyagi1, Barry D Kuban1
1Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Artificial organs
|February 1, 2025
概括
在使用连续流动的全人工心脏 (CFTAH) 作为双心室辅助装置 (BVAD) 时,心房管道 (AC) 与心室管道 (VC) 相比,提供更高的总流量和膜流量. 然而,VC允许在双心室心力衰竭患者中更容易实现左右平衡.
科学领域:
- 心血管工程 心血管工程
- 生物医疗设备 生物医疗设备
- 心脏衰竭管理的管理
背景情况:
- 双心室辅助器件 (BVAD) 对于双心室心力衰竭的血液动力学支持至关重要.
- 对于BVADs,最优的输入管道策略,心房 (AC) 与心室 (VC) 相比,仍然没有定义.
- 这项研究使用AC和VC技术的连续流量全人工心脏 (CFTAH) 评估了BVAD性能.
研究的目的:
- 为了比较CFTAH的血液动力性能,使用心房管 (AC) 与心室管 (VC) 进行BVAD.
- 确定在模拟心力衰竭条件下实施BVAD的最佳通道化策略.
主要方法:
- 一个模拟循环系统与双脉动心室 (AB5000) 模拟本土的心脏功能.
- 一个CFTAH作为BVAD,对AC和VC输入配置进行了测试.
- 血液动力学参数包括压力 (LAP,RAP,AoP,PAP) 和流量 (Lin,Rin,Lout,Rout,LPF,RPF,TF) 在各种模拟心力衰竭情景下进行监测.
主要成果:
- 无论是AC还是VC,都显示出整体支持增加,大动脉和肺动脉压力更高.
- 耳前管道 (AC) 导致总流量 (TF) 和膜流量增加,尽管左侧和右侧的流量较低 (LPF,RPF).
- 腹腔管 (VC) 便于更容易地实现左右血动力学平衡,并降低左心房压力 (LAP).
结论:
- 在实施CFTAH作为BVAD时,心房通道 (AC) 受到青,因为它能够增加总流量和膜流量.
- 腹腔管 (VC) 在实现血液动力学平衡方面具有优势,特别是在管理左心房压力方面.
- 需要进行进一步的研究,以确定BVADs的最终最佳通道化策略.
相关概念视频
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Assessment of the Cardiovascular System IV: Auscultation
Cardiac auscultation is a clinical skill used to assess heart function and detect abnormalities. It involves listening to heart sounds at specific anatomical locations through a stethoscope.
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.
Cardiac Catheterization II: Right Heart Catheterization
Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
Cardiac Catheterization III: Left Heart Catheterization
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...


