创新的口腔膜输送系统用于高血压:结合坎德沙坦和基亚胺
Ola Tarawneh1, Aisha Kanan1, Walid Al-Zyoud2
1Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Journal of biomaterials applications
|February 1, 2025
概括
这项研究开发了针对高血压的新型口腔膜,结合了candesartan cilexetil和hydrochlorothiazide. 这些创新电影改善了药物输送,提高了患者的服药性,并绕过了第一通代谢,以有效管理高血压.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 心血管药理学心血管药理学
背景情况:
- 高血压管理需要有效的药物输送系统.
- 口腔药物输送在传统的口服途径上具有优势.
- 结合甘沙坦基列 (CC) 和酸 (HCTZ) 是一个治疗机会.
研究的目的:
- 开发和描述用于联合高血压治疗的新型口腔膜.
- 评估薄膜的物理化学,机械和生物粘合性质.
- 为了评估candesartan cilexetil和hydrochlorothiazide口膜的药物释放和均性.
主要方法:
- 溶剂造技术用于片的制备.
- 使用的聚合物包括PVA,PVP和CMC Na.
- 电影的特点是物理特性,药物含量,分解和生物粘合性.
- 动态机械热分析 (DMTA) 用于确认药物-聚合物混合性.
主要成果:
- 开发出具有中性的pH值和出色的折叠耐久性的视觉均的口腔膜.
- 含有PVA,PVP和CMC Na的配方显示出快速分解和优异的生物粘合性.
- DMTA证实了坎德沙坦基列和基在聚合物矩阵中的成功混合性.
- 经过优化后的薄膜显示出提高溶解度和生物可用性的潜力.
结论:
- 新的口腔膜为高血压治疗提供了一个有希望的替代方案.
- 这种输送系统通过简化管理来提高患者的遵从性.
- 绕过第一通代谢改善了坎德沙坦西莱克塞蒂尔和基亚的治疗疗效.
关键词:
坎德沙坦 (Candesartan) 是一种西莱克塞尔乙基的药物.在HPLC中使用HPLC.组合聚合物的聚合物.酸亚化物 酸亚化物口腔可分散薄膜 (ODF) 是一种在口腔中可分散薄膜.溶剂造技术是一种溶剂造技术.更多相关视频
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