重组CVA24v的流行病学特征和进化分析在中国再次出现的AHC疫情的背景下,2023年
Lei Zhou1, Qin Guo1,2, Liheng Yu1
1National Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Journal of medical virology
|February 1, 2025
概括
中国中国中国中国.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 急性出血性结膜炎 (AHC) 疫情在中国定期发生.
- 此前在全国范围内发生的AHC疫情是在2007年和2010年记录的.
- 2023年的疫情代表了二十年来第三次AHC重大事件.
研究的目的:
- 分析2023年中国AHC疫情的流行病学特征.
- 为了确定2023年AHC爆发的病原体.
- 调查流传中的Coxsackievirus A24变种 (CVA24v) 的遗传重组模式.
主要方法:
- 从2023年开始的病例数据的描述性流行病学分析.
- 病原体的隔离和识别.
- 病毒序列的分子分析,包括重组分析.
主要成果:
- 2023年AHC疫情在9月达到峰值,有195,297例病例.
- 鉴定出CVA24v的GIV基因型是病原体.
- 10-15岁的学生在海南,广西和广东省受到影响最多.
- 在CVA24v菌株中发现了七种不同的重组模式,涉及特定的基因组区域.
结论:
- 2023年AHC疫情与之前的事件具有流行病学相似之处.
- CVA24v GIV 基因型是中国反复发生的 AHC 爆发的主要原因.
- 病毒重组是CVA24v的一致特征,影响其分子流行病学.
- 结果为了解和管理未来的AHC爆发提供了关键数据.
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